Cortagen

How a course is commonly described

1. 1
   Days 1-10Community-reported

   Community guides describe starting at the full dose on day one, injected subcutaneously in the morning, with 10 days as the standard course and 1 mg a day as the conservative first course. They tell readers to expect nothing acute, framing the course as a gene-expression pulse rather than a drug with same-day effects.

2. 2
   Days 11-20Community-reported

   Extended courses of 15-20 days are described for neurological support at the higher 5-10 mg tier, and capsule courses run to 30 days. No source describes a taper or any marker for judging the course.

3. 3
   Months 1-6 offCommunity-reported

   A break of 3-6 months follows, during which guides claim the gene-expression changes are doing their work, and they describe the most noticeable results arriving only after two or three cycles spread over 12-18 months. None of this has been measured in people.

4. 4
   Repeat coursesCommunity-reported

   Courses are described as repeating one to three times a year, often in spring and autumn, following the seasonal pattern used across the Khavinson peptide family rather than anything specific to Cortagen.

5. 5
   Preclinical comparisonPreclinical

   The rat study gave 10 mcg/kg intramuscularly for 10 days and measured nerve regrowth months afterwards, and the mouse behavioural study dosed for 5 days at 0.01-0.10 mg/kg. Both are far below the community milligram courses once scaled to body weight, and neither tested repeat courses.

• The only dosed data are rodent: 10 mcg/kg intramuscularly for 10 days in rats and 0.01-0.10 mg/kg intraperitoneally in mice. The body-surface-area human equivalent of the rat dose is about 1.6 mcg/kg, which works out to roughly 0.1 mg for a 70 kg adult, well under the 1-10 mg daily courses described by community guides.
• No pharmacokinetic study exists in any species, so claims that Cortagen clears within minutes are class assumptions about short peptides rather than measurements, and nothing is known about repeated courses.
• Cortagen is not approved outside Russia and neighbouring countries and no trial is registered. The human reports are Russian-language, uncontrolled and combine it with the extract Cortexin, so the courses above record what guides describe, not tested regimens.