Peptides > Vesugen (Bioregulator)

Vesugen (Bioregulator)

Vesugen is a tripeptide with bioregulatory and geroprotective properties. Scientific research has demonstrated its ability to safeguard the vascular system against the effects of aging, particularly by limiting the development of atherosclerosis and reducing overall dysfunction of endothelial cells. The impact of Vesugen administration is most evident in systems that are particularly sensitive to vascular damage and decline, such as the central nervous system and the cardiovascular system. Vesugen appears to play a significant role in regulating the levels of sirtuin 1 protein, which has essential effects on metabolic processes and contributes to mitigating the effects of aging. Sirtuin 1 is activated through calorie restriction and is therefore believed to be one of the proteins responsible for the profound anti-aging effects associated with calorie restriction.

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1. What is Vesugen?


2. Vesugen Structure


3. Vesugen and the Brain


Vesugen, composed of the tripeptide Lys-Glu-Asp, primarily targets the vascular system, exerting significant effects throughout the body due to the systemic importance of the vascular system in various metabolic processes. Research indicates that Vesugen can enhance the survival of neurons in the central nervous system, reduce the occurrence of atherosclerosis and restenosis to safeguard blood vessels, and promote cell survival and tissue health throughout the body. Additionally, there is evidence suggesting that Vesugen may play a role in regulating addictive and reward-related behaviors. Notably, Vesugen is considered an anti-aging peptide, in part because it mimics some of the effects associated with calorie restriction, a well-known approach to promoting longevity.

Vesugen Structure

Amino Acid Sequence: Lys-Glu-Asp (KED)
Molecular Formula: C15H26N4O8
Molecular Weight:
 390.39 g/mol
PubChem CID: 87571363
Synonyms: lysylglutamyl aspartic acid, SCHEMBL3767701, CHEBI:159909

Vesugen and the Brain

Vesugen, a neuroprotective peptide, shows promise in the field of Alzheimer’s disease and central nervous system (CNS) function. Here are some key points about Vesugen:

  1. Memory Improvement: Vesugen has demonstrated the ability to improve memory in elderly individuals with CNS functional disorders. This suggests its potential as a treatment for Alzheimer’s disease, a condition characterized by memory impairment.

  2. Restoration of Synaptic Plasticity: The peptide has been shown to restore synaptic plasticity, which is essential for neurons to establish and strengthen connections. This property is crucial for overall brain function and cognitive health.

  3. Gene Regulation: Vesugen appears to regulate the expression of specific genes related to apoptosis (cell death) and neuron differentiation. Some of these genes are implicated in Alzheimer’s disease pathogenesis, making Vesugen a potential candidate for therapeutic intervention.

  4. Hypoxia Protection: Vesugen, along with other peptides like Epitalon, Pinealon, and Violon, has been found to mitigate the effects of hypoxia (oxygen deprivation) in the CNS. It accomplishes this by increasing the levels of anti-oxidative enzymes, which counteract neurotoxic reactive oxygen species generated during periods of oxygen deficiency.

  5. Potential in Neonatal Hypoxia: Vesugen’s ability to protect against hypoxia could have applications in various scenarios, including stroke, heart attacks, and neonatal hypoxia during childbirth. By reducing the damaging effects of oxygen deprivation, Vesugen may help preserve CNS function in these situations.

Research into Vesugen and its potential applications in neuroprotection, memory enhancement, and gene regulation is ongoing. While it holds promise, further studies and clinical trials are needed to fully understand its mechanisms of action and its effectiveness in treating conditions like Alzheimer’s disease and hypoxia-related disorders.

Vesugen, a tripeptide with neuroprotective and anti-aging properties, holds significant promise in various areas of health and longevity. Here are some key points about Vesugen and its potential benefits:

  1. Neuroprotection: Vesugen has demonstrated the ability to protect the central nervous system, including improving memory and restoring synaptic plasticity. These properties make it a potential candidate for the treatment of conditions like Alzheimer’s disease and CNS functional disorders.

  2. Vascular Health: Vesugen plays a crucial role in maintaining vascular health. It helps prevent the development of atherosclerosis, which can lead to the narrowing of blood vessels. By normalizing endothelin-1 expression and increasing sirtuin 1 expression, Vesugen promotes healthy blood circulation, ensuring the supply of nutrients and removal of waste products to support neuronal health.

  3. Gene Regulation: Vesugen appears to regulate the expression of genes involved in apoptosis, neuron differentiation, and other critical processes. Its impact on gene expression may contribute to its neuroprotective and anti-aging effects.

  4. Metabolic Benefits: Vesugen activates sirtuin 1, a protein associated with insulin sensitivity and metabolic regulation. This activation can enhance insulin sensitivity and help mitigate insulin resistance caused by factors like a high-fat diet.

  5. Addiction and CNS Regulation: Vesugen’s effects on sirtuin 1 extend to the regulation of dopaminergic neurons, which are essential for motivation, reward, and habit formation. This property may have implications for the treatment of addiction and various neurological disorders.

  6. Aging and Longevity: Vesugen’s activation of sirtuin 1 is comparable to the effects of calorie restriction, a known strategy for extending lifespan. By slowing down cellular aging processes, Vesugen has the potential to promote longevity and improve overall tissue and cell health.

  7. Geroprotective Effects: Research suggests that Vesugen exhibits significant geroprotective effects, particularly when administered to individuals with polymorbidity and organic brain syndrome. It slows the rate of aging, improves central nervous system activity, and positively impacts biological age indicators.

In summary, Vesugen’s multifaceted properties make it a promising peptide for addressing various aspects of health, including neuroprotection, vascular health, metabolic regulation, addiction management, and overall longevity. While more research is needed to fully understand its mechanisms of action and clinical applications, Vesugen offers exciting possibilities for improving both cognitive and physical well-being.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.


The product information featured on this website pertains exclusively to in-vitro studies. In-vitro studies, also known as ‘in glass’ studies, are conducted outside of living organisms. It’s important to emphasize that these products do not constitute medicines or drugs and have not received FDA approval for the prevention, treatment, or cure of any medical conditions, ailments, or diseases. It is crucial to note that the introduction of these products into the bodies of humans or animals is strictly prohibited by law.