Peptides > Sermorelin


Sermorelin, an analogue of growth hormone-releasing hormone (GHRH), is employed in clinical settings to evaluate the secretion of growth hormone. Researchers are intrigued by its potential to enhance bone density, minimize scarring, counteract the effects of dementia, and decrease seizure activity.

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1. What Is Sermorelin?


2. Sermorelin Peptide Structure


Sermorelin Peptide Research

1. What Is Sermorelin?

Sermorelin is among a group of growth hormone-releasing hormone (GHRH) analogues created in recent years, aiming to retain the beneficial effects of natural GHRH while avoiding unwanted side effects. Currently utilized in clinical settings to evaluate growth hormone secretion, Sermorelin (also known as Geref) has attracted attention for its potential to:

  1. Reduce scarring after a heart attack.
  2. Enhance bone density.
  3. Improve nutritional status in chronic illnesses.
  4. Enhance renal function.
  5. Counteract the effects of dementia.
  6. Decrease seizure activity. 

Sermorelin Peptide Structure

Sequence: Tyr-DL-Ala-DL-Asp-DL-Ala-DL-xiIle-DL-Phe-DL-xiThr-DL-Asn-DL-Ser-DL-Tyr-DL-Arg-DL-Lys-DL-Val-DL-Leu-Gly-DL-Gln-DL-Leu-DL-Ser-DL-Ala-DL-Arg-DL-Lys-DL-Leu-DL-Leu-DL-Gln-DL-Asp-DL-xiIle-DL-Met-DL-Ser-DL-Arg
Molecular Formula: C149H246N44O42S
Molecular Weight: 3357.933 g/mol
PubChem CID: 16129620

Sermorelin Peptide Research

1. Sermorelin and Heart Health

Heart attack, while acutely life-threatening, can also lead to long-term disability secondary to heart failure, cardiac conduction abnormalities (arrhythmias), reduced exercise capacity, pain, and more. A number of these problems result from cardiac remodeling that follows damage to myocytes (heart muscle cells). Often, cardiac remodeling leads not only to scarring in the area of damage following a heart attack, but in surrounding, undamaged areas as well. This remodeling causes a number of long-term problems and research has shown that preventing it from happening can significantly improve outcomes both immediately after heart attack and years down the line.

In 2016, a study in pigs revealed that sermorelin administration is effective in reducing the remodeling that follows a heart attack. The research showed that sermorelin:

  • reduces cell death in cardiomyocytes,
  • increases the production of extracellular matrix components needed for adequate healing,
  • increases the growth of blood vessels to damaged tissue, and
  • reduces the production of substances that causes damaging inflammation.

Clinically, sermorelin’s effects are seen in improved diastolic function, reduced scar size, and increased capillary growth[1][2]. There is current research exploring the benefits of sermorelin in other forms of heart disease, such as heart failure and even valve disorders.

GHRH treatment reduces scar mass. A. Shows graph of percent change in scar mass over time on top and the relationship between the percent change in scar mass as a percentage of left ventricular mass. B. Shows images of the heart before and after 4 weeks of sermorlin treatment or placebo.

2. Sermorelin and Epilepsy

Gamma-aminobutyric acid (GABA) is a central nervous system signaling molecule known to reduce electrical activity in the spinal cord and reduce overall electrical excitability in the central nervous system. A number of anti-seizure medications work either by increasing levels of GABA in the central nervous system or by binding to GABA receptors and mimicking the effects of GABA. In a recent study of mice with epilepsy, scientists administered GHRH analogues, like sermorelin, to test the effect of these peptides on seizure activity. It turns out that GHRH analogues are effective in suppressing seizures by activating GABA receptors[3]. This is a very new finding and an active area of research as medications for treating seizure conditions, while effective, have a range of detrimental side effects that reduce their clinical use.

3. Sermorelin and Sleep

There is good evidence that sleep cycles are regulated by orexin, a potent neurochemical produced by certain neurons in the brain. It is also well understood that growth and healing, which are strongly associated with growth hormone secretion, primarily take place during sleep. Research in rainbow trout suggests that this is no coincidence, with an intact GHRH axis being a necessary component for proper orexin secretion and function. In addition, the research reveals that exogenous administration of sermorelin and other GHRH agonists can boost orexin secretion [4]. There is ongoing research into the benefits of using sermorelin in sleep disorders.

4. Sermorelin Preferred to Growth Hormone

Sermorelin is a growth hormone releasing hormone derivative and, as such, produces all of the same effects that GH produces, including increasing muscle mass, boosting long bone growth, and reducing adipose tissue. Even though the effects are the same, the side effects are not. In fact, sermorelin is the preferred way to increase GH levels in humans, even over the exogenous administration of growth hormone itself. The primary reason for this preference is that sermorelin is subject to physiological feedback mechanisms that help to prevent common problems encountered with GH administration. These problems include overdose, improper dosing, and unintended side effects like edema, joint pain, and dysregulation of normal physiology[5].

A second reason to prefer sermorelin is that research shows it is not subject to tachyphylaxis, the process by which the body becomes accustomed to a medication and requires higher and higher doses to achieve desired effects. In some cases, tachyphylaxis is so severe that a drug holiday (complete cessation of use of a medication) is required to regain the effects of a medication. Long-term use of sermorelin in certain clinical settings as well as animal studies of the peptide indicate that the body has a unique response to the peptide. Rather than down-regulate the production of GHRH receptors with administration of sermorelin, the body instead increases their production. This ensures that sermorelin’s effects are unchanged, that tachyphylaxis does not develop to a substantial degree, and that dose escalation is generally not required[6].

Sermorelin exhibits moderate side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Sermorelin for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy Sermorelin if you are a licensed researcher.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.


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