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Oxytocin (6000 IU)

Oxytocin, a naturally occurring protein hormone, serves significant roles in various physiological processes, including sexual reproduction, childbirth, fostering the bond between mother and child during breastfeeding, and facilitating wound healing. Recent studies have indicated that it may also have potential benefits in enhancing cognitive performance, reducing cardiovascular risks, and counteracting the impacts of diabetes.

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.

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1. Oxytocin Overview

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2. Oxytocin Structure

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3. What Is Oxytocin?

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4. Oxytocin Research

Oxytocin Overview

Oxytocin can be viewed as a single protein with two distinct natural functions. First and foremost, it operates as a neuropeptide, released by the hypothalamus, and holds crucial roles in processes related to bonding, sexual reproduction, and childbirth. Additionally, oxytocin serves as a conventional blood-borne hormone, predominantly produced by the placenta in pregnant women, influencing childbirth, milk production, and the establishment of bonds with newborns. In men, a small quantity of oxytocin is generated in the testes, contributing to mating behavior and pair bonding. Research on oxytocin has uncovered its involvement in various functions, including:

  1. Facilitating milk ejection and lactation.
  2. Triggering uterine contractions during childbirth.
  3. Regulating blood pressure.
  4. Modifying neuron function.
  5. Enhancing social bonding.
  6. Influencing fear and anxiety responses.
  7. Impacting mood.
  8. Promoting wound healing. 

Oxytocin Structure

Sequence: Cys(1)-Tyr-Ile-Gln-Asn-Cys(1)-Pro-Leu-Gly
Molecular Formula: C43H66N12O12S2
Molecular Weight: 1007.193 g/mol
PubChem CID: 439302
CAS Number: 50-56-6
Synonyms: Pitocin, Endopituitrina, Ocytocin

What Is Oxytocin?

Oxytocin is a short peptide, consisting of just nine amino acids, initially synthesized in the hypothalamus and later released by the posterior pituitary gland. It is not limited to these organs, as it is also produced by the placenta, ovaries, and testes. Similar to many peptide hormones, syntocinon originates from a larger precursor molecule and undergoes cleavage to form the active hormone. Interestingly, syntocinon has been detected in other body tissues as well, including the retina, adrenal glands, thymus, and pancreas. While syntocinon has traditionally been viewed as a neurohypophysial hormone, this perspective is evolving as researchers uncover its potential effects on various tissues beyond the nervous system.

Oxytocin Research

Oxytocin’s Impact on Wound Healing Oxytocin, a hormone often associated with bonding and social interactions, possesses the intriguing ability to influence inflammation by acting on specific inflammatory cytokines. A noteworthy experiment involving 37 couples revealed a compelling connection between social interactions and wound healing. It was observed that interactions leading to higher syntocinon levels were linked to an acceleration in the wound healing process. Remarkably, the rate of wound healing correlated positively with syntocinon levelsÔÇöhigher levels equated to faster healing1. Further research in this realm has illuminated how interpersonal relationships, particularly within couples, can exert a significant impact on wound healing. Hostile interactions, for instance, were found to reduce wound healing rates by as much as 40%. Additionally, such couples exhibited lower levels of certain inflammatory markers, including IL-6, tumor necrosis factor alpha, and IL-1beta, at the wound site2.

Exploring Oxytocin’s Role in Cardiovascular Health Given its potential to enhance wound healing and regulate inflammatory cytokines, researchers have speculated about syntocinon’s impact on cardiovascular health. syntocinon has demonstrated its ability to reduce fat mass, improve glucose tolerance, lower blood pressure, and alleviate anxiety1, all of which are significant factors in cardiovascular disease (CVD). This suggests that syntocinon could be a valuable complement to existing CVD treatments.

There is substantial evidence indicating that atherosclerosis, a key factor in CVD, may develop due to the suppression of syntocinon receptor expression. Elevating syntocinon levels in individuals with reduced receptor density has been shown to maintain cardiovascular integrity and, in some instances, even reverse atherosclerosis2.

Studies in rats have indicated that direct infusion of syntocinon into the heart during ischemia (such as a heart attack) can protect cardiomyocytes (heart muscle cells) from cell death. Additionally, chronic oxytocin treatment may prevent the development of dilated cardiomyopathy and potentially enhance cardiac stem cell function, aiding in tissue regeneration3.

Further research in mice has revealed that syntocinon treatment can mitigate heart damage associated with diabetes. In these mice, syntocinon reduced body fat accumulation by 19% and lowered fasting glucose levels by 23%, primarily by improving insulin sensitivity. As a result, mice treated with syntocinon displayed reduced systolic and diastolic dysfunction, leading to decreased cardiomyocyte hypertrophy, fibrosis, and apoptosis4.

Oxytocin’s protective effects against ischemic injuries extend beyond heart tissue. Research in rats with priapism (persistent erection) suggests that syntocinon administration can shield against ischemia-reperfusion injury by reducing nitric oxide levels5.

Management of Diabetes with Oxytocin likely enhances glucose uptake in skeletal muscles by increasing insulin sensitivity, making it a potential candidate for diabetes treatment. Research in mice has also highlighted syntocinon’s role in lipid utilization, reducing overall body fat mass and rates of dyslipidemia. Notably, deficiencies in oxytocin have been linked to obesity, even in cases of normal food intake and exercise, emphasizing its role in energy homeostasis6.

Interestingly, studies in lean and obese mice have shown that syntocinon treatment does not affect glucose, insulin, and body composition in lean mice but has a significant impact on these parameters in obese mice. This suggests that while syntocinon is beneficial in managing certain aspects of diabetes, its effects may vary depending on the context7. In a study involving patients with diabetes, intranasal syntocinon reduced glucose and insulin levels and led to a 9 kg weight loss over eight weeks. Circulating syntocinon was found to be lower in individuals with type 2 diabetes compared to those with normal glycemic levels, and it was negatively correlated with glycosylated hemoglobin A1C and insulin resistance8.

Cognitive Performance and Oxytocin Research has long indicated that early maternal deprivation can result in lasting cognitive and behavioral alterations. Studies in mice have suggested that these changes may be due, in part, to syntocinon fluctuations resulting from reduced parental bonding. In one study, maternally deprived mice treated with oxytocin exhibited improvements in hormone levels associated with neuron development in the prefrontal cortex. While no significant overall behavioral differences were observed, there was a trend toward better cognitive performance in the oxytocin-treated group9. Other research in mice has also shown that intranasal syntocinon can enhance learning, particularly in stressful situations10.

Unveiling Oxytocin’s Impact on Anxiety and Depression Numerous studies have suggested a correlation between oxytocin and anxiety and depression. Genetic variations in the oxytocin receptor gene have been linked to conditions like social anxiety disorder and attachment problems during childhood[^13^]. Additionally, in untreated individuals with social anxiety, epigenetic changes within the oxytocin receptor gene have been observed, indicating a possible compensatory mechanism for abnormally low oxytocin levels[^14^]. These findings imply that reduced oxytocin signaling may contribute to social anxiety.

Shedding Light on Oxytocin and Borderline Personality Disorder (BPD) Borderline Personality Disorder (BPD), an extreme form of social anxiety disorder, has recently been associated with dysregulation of oxytocin. BPD is characterized by heightened threat perception, extreme mistrust, and altered non-verbal social behavior. Administration of intranasal oxytocin to individuals with BPD has demonstrated modifications in these behaviors, offering hope for a better understanding of the condition and potential avenues for improved treatment[^15^].

Exploring Oxytocin’s Role in Hunger Regulation Research conducted in Prader-Willi syndrome, a condition characterized by uncontrollable appetite, has indicated that the over-suppression of oxytocin signaling may contribute to its pathophysiology. This suggests that oxytocin may play a role in hunger regulation and could directly influence feeding behavior[^16^].

Oxytocin’s Influence on Aging Muscles Emerging research has unveiled oxytocin as a crucial component in maintaining and repairing healthy muscles, shedding light on its potential role in addressing age-related muscle wasting, known as sarcopenia. Studies conducted at Berkeley have shown that declining oxytocin levels with age lead to a reduction in oxytocin receptors on muscle stem cells. Administering oxytocin can swiftly reverse this effect, allowing aging muscles to regain much of their capacity for healing. This breakthrough holds promise for intervening in age-related organ degeneration and slowing dysfunction[^17^].

Please note that oxytocin is solely intended for educational and scientific research purposes, and it is not for human consumption. Purchase and use of oxytocin should be limited to licensed researchers.

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Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.

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The product information featured on this website pertains exclusively to in-vitro studies. In-vitro studies, also known as ‘in glass’ studies, are conducted outside of living organisms. It’s important to emphasize that these products do not constitute medicines or drugs and have not received FDA approval for the prevention, treatment, or cure of any medical conditions, ailments, or diseases. It is crucial to note that the introduction of these products into the bodies of humans or animals is strictly prohibited by law.