Peptides > N-Acetyl Semax Amidate

N-Acetyl Semax Amidate

N-Acetyl Semax, a synthetic peptide, has gained recognition for its remarkable neurogenic and neurorestorative qualities. Although it has received clinical approval in Russia, its potential benefits have yet to be explored in other regions. Extensive research suggests that N-Acetyl Semax can enhance memory and cognitive function, offering promise in addressing conditions like optic nerve disorders, stroke, and ischemic heart disease. Furthermore, there is evidence to suggest that it may have a positive impact on immune function. Explore the possibilities with N-Acetyl Semax today.

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.


1. Introduction to N-Acetyl Semax Amidate


2. Molecular Structure


3. Reasearch on N-Acetyl Semax Amidate

Introduction to N-Acetyl Semax Amidate

Semax: A Multifaceted Russian Nootropic

Semax, a nootropic initially developed in Russia, boasts a wide array of potential benefits across various medical contexts. This versatile compound has shown promise in the realms of stroke recovery, cognitive impairment, dementia management, and alleviating inflammation of the optic nerve. Moreover, it has undergone testing as a potential immune system enhancer, yielding promising results. Beyond these applications, Semax has demonstrated its potential as an antidepressant and anxiolytic, providing relief in the realm of mental health.

The research findings are compelling, revealing that Semax’s mechanism of action involves the elevation of crucial neurotransmitters and growth factors. Notably, it increases levels of brain-derived neurotrophic factor (BDNF) within the central nervous system, a key player in neuronal health and synaptic plasticity. Additionally, Semax has been shown to modulate levels of serotonin and dopamine, further underscoring its potential in promoting cognitive and emotional well-being.

What is Semax?
Semax is a synthetic analogue of adrenocorticotropic hormone (ACTH). It consists of the amino acids 4-10 of ACTH. 

Molecular Structure of N-Acetyl Semax Amidate

Image of Semax without the N-acetyl side chain

Here in the sequence, “Ac-” represents the Acetyl group attached to the N-terminus of the peptide, and “-NH2” represents the Amidated group at the C-terminus. The amino acid sequence “MEHFPGP” corresponds to the core Semax peptide. Acetyl-Semax-Amidate is a modified version of Semax, a synthetic peptide with nootropic and neuroprotective properties, and these modifications may enhance its stability, bioavailability, and efficacy.

Sequence: Ac-TPRKEPV-NH2
Molecular Formula: C37H51N9O10S
Molecular Weight: 858.977036 g/mol

Research on N-Acetyl Semax Amidate

Semax: Enhancing Brain Function and Cognitive Health

Semax, a product developed in Russia, has garnered attention for its potential benefits in various health settings, including stroke recovery, cognitive impairment, dementia, and inflammation.

Improving Resting Brain Structure with N-Acetyl Semax

Functional magnetic resonance imaging (fMRI) has shed light on how Semax positively impacts brain function. Specifically, it enhances the activity of the default mode network, a network that becomes more active during rest than during task performance. This network is vital for social cognition and environmental monitoring, making it crucial for our overall attention. Conditions affecting cognition, like Alzheimer’s disease, often involve compromised default mode network activity, reinforcing its importance in social awareness.

By increasing default mode network activity, N-acetyl Semax heightens our general alertness during rest, particularly in social contexts. This heightened awareness allows for better focus and attention, facilitating the transition from a resting state to a focused one.

Moreover, enhanced default mode network activity correlates with increased connectivity across different brain regions. While there is no direct evidence of Semax’s impact on brain connectivity, it’s conceivable that this peptide fosters greater interconnectivity, potentially resulting in improved problem-solving abilities, memory, and creativity.

N-Acetyl Semax in Stroke Recovery

In Russia, N-acetyl Semax is employed for treating acute cerebral hypoxia, such as that occurring in stroke or traumatic brain injury. Studies in rats reveal that N-acetyl Semax triggers various molecular mechanisms related to gene transcription in the central nervous system (CNS). Notably, it influences the expression of 24 genes linked to brain and spinal cord blood vessel function. These genes regulate processes like smooth muscle cell migration, red blood cell formation, and new blood vessel formation. This might explain why N-acetyl Semax displays neuroprotective properties during stroke, promoting neuron survival, stabilizing mitochondria, and enhancing brain nutrition.

Research on stroke patients in Russia indicates that N-acetyl Semax accelerates the recovery rate and leads to improved overall function after therapy. Early rehabilitation combined with Semax administration raises brain-derived neurotrophic factor (BDNF) plasma levels, expediting functional recovery and enhancing motor performance.

BDNF is a natural peptide crucial for learning and memory, suggesting that N-acetyl Semax, by stimulating BDNF, may enhance brain plasticity, making it easier for undamaged brain regions to take over tasks previously handled by damaged ones. Furthermore, Semax activates the default mode network, as mentioned earlier, a key component of resting attention and social function.

N-Acetyl Semax and Brain Gene Expression

The impact of N-acetyl Semax on gene expression isn’t limited to stroke recovery. Studies in healthy rats demonstrate that a single intranasal administration of Semax affects multiple genes in the hippocampus and frontal cortex within 20 minutes. These brain regions are critical for memory, learning, concentration, planning, and information organization. Semax’s effects on nerve growth factor (NGF) and BDNF are particularly noteworthy. Researchers speculate that Semax may hold promise in unraveling how we learn and process information, potentially enhancing cognition and learning.

Enhancing Cognitive Performance with N-Acetyl Semax

Emerging evidence suggests that N-acetyl Semax could be effective in boosting learning and memory, especially in individuals with neurological impairments. Studies show that ACTH, the natural protein upon which N-acetyl Semax is based, protects learning and memory in mouse models of epilepsy. ACTH has long been used to treat epileptic disorders as a means of safeguarding against learning and memory deficits during seizures.

N-acetyl Semax, a derivative of ACTH, may offer unique advantages. While more research is needed, it’s worth noting that even low doses of ACTH can prevent learning and memory dysfunction during seizures. This suggests potential nootropic properties of ACTH and Semax, with the possibility of enhancing cognitive performance through regular, low-dose administration.

N-Acetyl Semax and Depression

Studies in mice suggest that increasing BDNF levels can regulate brain function in depression. Current antidepressants, like SSRIs, often take weeks to show effects, but the delayed response has been puzzling. Insight from N-acetyl Semax and other BDNF stimulators suggests that SSRIs may work by increasing BDNF levels, stimulating neurogenesis in depressed brains. Combining BDNF stimulators, such as N-acetyl Semax, with SSRIs may enhance efficacy and revolutionize depression treatment.

It’s important to note that N-Acetyl Semax exhibits minimal side effects and excellent bioavailability. However, it is intended for research purposes only and should not be used for human consumption without proper licensing.

Image showing the overlap of activation between the resting mode network and parts of the brain responsible social cognition.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.


The product information featured on this website pertains exclusively to in-vitro studies. In-vitro studies, also known as ‘in glass’ studies, are conducted outside of living organisms. It’s important to emphasize that these products do not constitute medicines or drugs and have not received FDA approval for the prevention, treatment, or cure of any medical conditions, ailments, or diseases. It is crucial to note that the introduction of these products into the bodies of humans or animals is strictly prohibited by law.