MK-677 (Ibutamoren)

MK-677 and Somatopause: The progressive decline of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) with age is known as somatopause. It leads to changes in body composition and muscle function, especially in the elderly. While men at 70 years produce only about 60% of the GH they did at 18, estrogen and progesterone can elevate GH and IGF-1 levels in women, mitigating the effects of somatopause.

MK-677 and Body Composition: MK-677 shows promise in potentially slowing somatopause progression. In a two-year controlled trial, daily oral MK-677 administration (25 mg) significantly increased GH and IGF-1 levels, resulting in a modest weight gain of approximately 2 kg without affecting strength or fat mass. It also improved bone density and had some effects on cholesterol levels. MK-677 could potentially address negative nitrogen balance caused by low protein intake, offering clinical benefits in various health conditions, including sarcopenia.

MK-677 and Bone Density: Research in both young obese males and elderly individuals indicates that MK-677 can influence bone remodeling, potentially improving bone strength and resistance to fractures, particularly when combined with weight training. Some studies suggest positive effects on gait speed and fall reduction in elderly patients with hip fractures. However, further research is needed to fully understand its impact.

MK-677 and Neurological Function: IGF-1 plays a role in clearing amyloid beta from the central nervous system, a key factor in Alzheimer’s disease (AD). While MK-677 increases IGF-1 levels in elderly patients, it doesn’t alter AD progression once diagnosed. Animal studies, though, suggest that MK-677 could be a preventative measure, reducing amyloid beta deposition and neuron loss when started before significant accumulation occurs.

MK-677 and Sleep: MK-677 has significant effects on sleep, particularly in older adults, increasing REM sleep duration and potentially aiding in muscle recovery, brain function, and development. Prolonged REM sleep could offer valuable insights into the function of sleep.

MK-677 and Heart Health: Aging leads to a decline in stem cell function, including endothelial progenitor cells (EPCs) important for blood vessel regeneration. Increased GH levels, as influenced by MK-677, may reverse the age-related decline in EPCs, potentially reducing the risk of heart disease. Additionally, GH treatment can increase nitric oxide levels, which regulate blood vessel health and blood pressure, potentially benefiting cardiovascular health.

MK-677 Summary: MK-677, a non-peptide ghrelin/growth hormone secretagogue agonist, elevates GH and IGF-1 levels in animal and human testing. It appears safe with minimal side effects but is not yet approved for widespread human use. Research indicates potential benefits in appetite regulation, body composition, muscle strength, cardiac health, and neurological function. Long-term use as a preventative measure may offer the most significant advantages, especially in the context of age-related diseases.