Peptides > PEG MGF


PEGylated Mechano-Growth Factor is a modified form of MGF, itself a modified form of IGF-1. Research has shown it to lower cholesterol and total body fat, boost immune function, and improve rates of wound healing.

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1. PEG MGF Overview


2. Molecular Structure of PEG MGF


3. What is PEG MGF?


4. Research on PEG MGF

Introduction to PEG MGF

Pegylated Mechano-growth Factor, abbreviated as PEG-MGF, is a modified version of insulin-like growth factor 1 (IGF-1). Scientific studies have demonstrated its ability to promote the proliferation and differentiation of myoblasts, which are muscle cells. PEG-MGF has also been investigated for its potential benefits in enhancing endurance, strengthening the immune system, reducing cholesterol levels, and decreasing overall body fat. Furthermore, there is some indication that PEG-MGF may expedite wound healing by improving immune function, potentially shortening the healing process.

Molecular Structure of PEG MGF

Sequence: PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-Cys
Molecular Formula: C121H200N42O39
PubChem SID: 178101669
Synonyms: Pegylated MGF, PEG IGF-1 Ec, PEG myotrophin

What is PEG MGF?

Pegylation Process: Pegylation is a chemical modification process that involves attaching polyethylene glycol (PEG) to another compound. This modification serves various purposes, including reducing the body’s natural immune response to the compound and extending its half-life in the bloodstream by minimizing kidney clearance. Pegylation is a widely used and safe technique with several benefits.

PEG-MGF for Extended Half-Life: PEG-MGF was developed in response to the short half-life of MGF (Mechano Growth Factor) in the bloodstream. When administered exogenously, MGF has a brief presence in the bloodstream due to rapid clearance unless it is directly injected into muscle tissue. PEG-MGF is designed to address this limitation, offering an effective solution to extend the presence of MGF in the body.

Research on PEG MGF

PEG-MGF and Skeletal Muscle

Muscle injuries are commonplace in sports, ranging from strains to avulsion injuries, often necessitating surgical intervention. Recovery from these injuries is typically protracted and outcomes can be imperfect. Studies in a mouse model of muscle injury have indicated that direct injection of MGF into the muscle can protect cells by reducing the expression of specific inflammatory hormones and mitigating oxidative stress.

Further research by Sun et al. has demonstrated that MGF plays a role in modulating muscle inflammation and enhancing the recruitment of macrophages and neutrophils to the injury site. Both studies build upon the knowledge that exercise-induced muscle damage triggers the release of IGF-1Ea and IGF-1Eb, closely related to MGF.

An international team of endocrinology researchers has also shown that MGF stimulates the insulin-like growth factor 1 receptor, similar to IGF-1. Activation of this receptor has been linked to benefits such as reduced aging, increased lean body mass, and improved energy balance in humans. This suggests that PEG-MGF may yield effects akin to IGF-1, promoting enhanced muscle repair, improved fat metabolism, and increased lean body mass.

In mouse research, the administration of MGF during exercise has led to a remarkable 25% increase in mean muscle fiber size. Notably, PEG-MGF addresses a limitation by prolonging MGF’s plasma half-life, enabling single intravenous injections rather than multiple intramuscular ones.

PEG-MGF Research in Heart Muscle Repair

Research conducted in the University of Illinois’ bioengineering department has uncovered that MGF can inhibit programmed cell death in cardiac muscle cells following hypoxia. Moreover, the peptide seems to attract cardiac stem cells to the injury site, potentially aiding in regeneration and healing post-heart attack. Rats receiving MGF within eight hours of hypoxia demonstrated reduced cell death and increased stem cell recruitment compared to control subjects.

Similar research highlights that localized delivery of MGF can enhance cardiac function after a heart attack by mitigating pathologic hypertrophy. Rats treated with PEG-MGF exhibited better hemodynamics and less cardiac remodeling than untreated rats. Carpenter et al. also demonstrated that MGF administration during acute myocardial infarction can reduce cardiomyocyte injury by up to 35%.

Bone Repair and Growth

Studies in rabbits have indicated that PEG-MGF can accelerate bone repair by boosting osteoblast proliferation, the cells responsible for bone mineralization. Rabbits receiving high doses of MGF exhibited equivalent healing at four weeks compared to the six-week healing seen in control subjects. This research offers promise for accelerating bone healing and reducing the duration of immobilization following injuries.

Protecting Cartilage

Research has shown that MGF can enhance the function of chondrocytes, crucial for cartilage health. In mice, MGF was found to facilitate the migration of chondrocytes from bone to cartilage, a suitable application for PEG-MGF, which could be injected into compromised joint spaces, providing extended therapeutic effects compared to standard MGF.

Dental Applications

In cell cultures of human periodontal ligament cells, PEG-MGF has demonstrated the potential to improve osteogenic differentiation and enhance the expression of MMP-1 and MMP-2. These factors aid in the repair of tooth-supporting ligaments, potentially offering an alternative to extractions and implants, preserving natural teeth after injury. PEG-MGF may even make it feasible to salvage damaged or avulsed teeth after surgical re-implantation.

Potential Neuroprotective Effects

Recent research has explored the long-term effects of elevated MGF levels in the brain and central nervous system. Elevated MGF levels have been associated with a reduction in age-related neuron degeneration, leading to improved cognitive function in mice as they age. These benefits appear to be more pronounced when MGF overexpression occurs earlier in life.

Treatment with MGF has also shown promise in improving muscle weakness and reducing motor-neuron loss in mouse models of ALS. MGF’s natural expression in the brain following hypoxic injury suggests that administering exogenous MGF may mitigate the impact of several neurological diseases, not by addressing their root causes but by preventing neuronal death in the brain and spinal cord despite ongoing disease processes.

It’s important to note that PEG-MGF exhibits minimal side effects and has excellent bioavailability in animal models. However, its dosage in mice does not scale to humans. Consequently, PEG-MGF is available for sale exclusively for educational and scientific research purposes, not for human consumption. It should only be acquired by licensed researchers.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.


The product information featured on this website pertains exclusively to in-vitro studies. In-vitro studies, also known as ‘in glass’ studies, are conducted outside of living organisms. It’s important to emphasize that these products do not constitute medicines or drugs and have not received FDA approval for the prevention, treatment, or cure of any medical conditions, ailments, or diseases. It is crucial to note that the introduction of these products into the bodies of humans or animals is strictly prohibited by law.