Peptides > Livagen


Livagen is a brief bioregulatory peptide with a direct impact on DNA structure and function. Its primary attribute lies in its ability to decondense chromatin, ultimately enhancing the expression of specific genes and rejuvenating cell vitality. Its most extensively researched effects are observed in lymphocytes within the immune system, where it is shown to activate immune responses and counteract ailments affecting the heart, gastrointestinal tract, immune system, and central nervous system. Furthermore, ongoing research also demonstrates its potential in managing nociception and pain. Continuous investigations aim to unveil Livagen’s potential, advancing our understanding of the aging and senescence processes.

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1. Introduction to Livagen


2. Molecular Structure of Livagen


3. How Does Livagen Works?

Introduction to Livagen

Livagen, a short peptide closely related to Epitalon (aka Epithalon), is recognized for its impact on the immune system, gastrointestinal (GI) tract, and liver. Functioning as a peptide bioregulator, Livagen directly influences DNA and gene expression patterns. Its alleged anti-aging attributes are believed to stem from Livagen’s capacity to activate genes within the GI tract and immune system that typically become inactive due to DNA condensation with aging.


Molecular Structure of Livagen

Amino Acid Sequence: Lys-Glu-Asp-Ala
Molecular Formula: C18H31N5O9
Molecular Weight: 461.5 g/mol
PubChem CID: 87919683
CAS No: 195875-84-4 (Deprecated: 402856-42-2)
Alternative Names: SCHEMBL5967826

How Does Livagen Works?

DNA Organization in Eukaryotes

DNA resides within the nucleus of eukaryotic organisms, such as humans, and undergoes a hierarchical organization to fit the approximately 3 feet of DNA within a human cell into a space just one-hundredth of a millimeter in size. This packaging process effectively reduces the DNA’s size by about 100,000 times.

The DNA double helix wraps around proteins known as histones, which assemble into chromatin structures. These chromatin structures further condense to form chromosomes. This hierarchical organization serves various purposes, including facilitating DNA replication and cell division, accommodating DNA within cells, and regulating gene expression at a high level. In essence, DNA organization primarily involves packaging genetic material and controlling access to specific genes.

Chromatin’s Role in Gene Expression Control

One significant function of chromatin is controlling gene expression.

Research conducted on older adults suggests that Livagen can activate specific genes in the lymphocytes of older individuals by decondensing chromatin. This activation includes genes, such as ribosomal genes, which indirectly contribute to enhanced protein production and increased cell activity. This information implies that Livagen has a direct impact on the DNA within lymphocytes, primary immune system cells.

Studies examining the effects of Livagen, Epitalon, and Vilon administration in elderly individuals reveal four different effects of Livagen on lymphocytes:

  1. Activation of synthetic processes by reactivating ribosomal genes.
  2. Decondensation of chromatin.
  3. Alteration of gene expression.
  4. Induction of decondensation.

All these effects collectively lead to the reactivation of silenced chromatin, potentially rejuvenating lymphocytes to a more youthful state.

Lymphocytes and Immune System

Lymphocytes represent a class of white blood cells that include B cells and T cells. B cells produce antibodies against foreign invaders, while T cells eliminate infected cells or cancerous cells, in addition to producing cytokines, which coordinate immune responses and control inflammation. Lymphocytes are vital components of the immune system, and their decline in activity with age contributes to increased susceptibility to various diseases.

Resetting lymphocytes to a more youthful state through Livagen could potentially enhance the body’s ability to combat infections and cancer.

Livagen’s Impact on Cardiac Health

Lymphocytes also play a crucial role in cardiac health. Research suggests that dysregulation of chromatin structure in lymphocytes is a contributing factor to conditions like hypertrophic cardiomyopathy (HCM) and atherosclerosis. Livagen’s ability to decondense chromatin aligns with this problem and has prompted extensive research.

By influencing lymphocyte gene expression, Livagen may reduce inflammation and scarring associated with heart disease. It might also be useful in preventing HCM in genetically predisposed individuals and aiding recovery after a heart attack or other cardiac injuries, potentially lowering morbidity and mortality related to heart disease.

Livagen and Pain Management

Livagen impacts pain management by inhibiting enkephalin-degrading enzymes in the blood, thereby increasing natural painkiller levels in the body. Ongoing research is investigating its effectiveness in pain control, potential side effects related to enhanced enkephalin levels, and any addictive potential.

Livagen and the Gastrointestinal Tract

Recent research indicates that Livagen affects the mucosal barrier of the gastrointestinal (GI) tract. Activation of mu and delta receptors by Livagen increases vagal nerve signaling to the GI tract and alters mucosal nitric oxide and prostaglandin levels. This leads to significant gastroprotection, potentially beneficial in treating infectious diarrhea and mitigating symptoms and long-term effects of inflammatory bowel disease.

Livagen’s ability to enhance receptor activation by increasing enkephalin levels suggests its potential use in various GI tract disorders.

Livagen and Aging

Research has revealed that many aging-related effects stem from changes in DNA organization, specifically chromatin condensation. This condensation silences genes and impairs repair processes, accelerating aging. Reversing this process by decondensing DNA may extend lifespan.

Studies by Professor Teimuraz Lezhava suggest that Livagen, Epitalon, and other bioregulatory peptides impact this process by decondensing DNA. This research provides hope that these peptides can counteract age-related dysfunctions, particularly in immune regulation and protein synthesis.

Summary of Livagen

In summary, Livagen is a bioregulatory peptide with direct effects on DNA structure and function. It is renowned for its ability to decondense chromatin, leading to increased gene expression and rejuvenation of cells. Livagen’s most extensively studied effects are on immune system lymphocytes, offering potential benefits in heart health, pain management, GI tract disorders, and aging-related dysfunctions. Research continues to uncover Livagen’s promise, shedding light on the processes of aging and senescence.

Please note that Livagen is primarily intended for educational and scientific research, and it is not meant for human consumption without proper licensing.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.


The product information featured on this website pertains exclusively to in-vitro studies. In-vitro studies, also known as ‘in glass’ studies, are conducted outside of living organisms. It’s important to emphasize that these products do not constitute medicines or drugs and have not received FDA approval for the prevention, treatment, or cure of any medical conditions, ailments, or diseases. It is crucial to note that the introduction of these products into the bodies of humans or animals is strictly prohibited by law.