Peptides > GHRP-2


GHRP-2 is a synthetic growth hormone secretagogue that interacts with the ghrelin/growth hormone secretagogue receptor. Research trials have demonstrated its potential to enhance muscle growth, modulate the immune system, and regulate sleep cycles. Remarkably, GHRP-2 research has revealed its ability to exhibit oral bio-activity, meaning it can have effects when taken orally.

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1. What is GHRP-2?


2. GHRP-2 Structure


3. GHRP-2 Effects

What is GHRP-2?

GHRP-2, also known as pralmorelin, is a synthetic growth hormone secretagogue that binds to the ghrelin/growth hormone secretagogue receptor. It was the pioneering compound among growth hormone secretagogues and is currently utilized as a test peptide to evaluate growth hormone deficiency and secondary adrenal failure. GHRP-2 has undergone stage II clinical trials to assess its potential in treating short stature and is actively investigated for its impact on appetite, muscle growth, the immune system, and sleep patterns. Notably, GHRP-2 can be administered orally and sublingually, eliminating the need for injections to achieve its effects.

GHRP-2 Structure

Sequence: D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys
Molecular Formula: C45H55N9O6
Molecular Weight: 817.9749 g/mol
PubChem CID: 6918245
CAS Number: 158861-67-7
Code Names: KP-102, GPA-748, WAY-GPA-748

GHRP-2 Effects

1. Muscle Savior: Research conducted on Yaks has unveiled the muscle-boosting potential of GHRP-2, primarily through two mechanisms: enhanced protein deposition and reduced protein degradation. In yaks facing growth plateaus due to factors like food scarcity, disease, or harsh environmental conditions, GHRP-2 emerged as a solution, effectively countering muscle atrophy. The peptide achieves this by deactivating proteins like atrogin-1 and MuRF1, which regulate the muscle degradation pathway. This discovery holds promise for combatting catabolism prevalent in chronic conditions such as autoimmune diseases and cancer. By activating growth hormone and insulin-like growth factor-1, GHRP-2 also contributes to increased muscle protein deposition, fostering the development of lean body mass even in challenging circumstances.

2. Appetite Igniter: GHRP-2 has demonstrated its ability to ramp up food consumption. While this might not appear immediately significant, stimulating appetite can play a crucial role in managing chronic illnesses. The capacity to reliably boost appetite offers doctors a valuable tool for treating long-term patients, ultimately enhancing their overall well-being and prognosis.

3. Heart Protector: Studies conducted on fetal heart cell culture lines have unveiled the potential of GHRP-2, along with its analogues (GHRP-1 and GHRP-6), to safeguard heart cells by reducing programmed cell death, known as apoptosis. This discovery holds particular significance in the context of heart attacks, where heart cells are highly vulnerable to apoptosis due to reduced blood flow and nutrient supply. Research involving the GHRP-2 analogue Hexarelin has hinted at the existence of a specific receptor for these peptides. The identification of such receptors not only paves the way for drug development but also enhances our understanding of human physiology and strategies to prevent dysfunction in the first place.

4. Immune Booster: GHRP-2 has demonstrated its ability to stimulate the thymus, a crucial organ responsible for safeguarding specific immune system cells, particularly aiding in the maturation of T cells. T cells play a pivotal role in adaptive immunity, enabling the body to combat complex infections effectively. As the thymus’s function tends to decline with age, various age-related dysfunctions emerge, spanning from impaired tissue repair to compromised immunity. This immune-boosting peptide rejuvenates the thymus, resulting in increased production of T cells with greater diversity. This, in turn, enhances overall immunity, bolstering the body’s ability to fend off infections, protect against cancer, and maintain normal tissue function.

5. Sleep Enhancement: GHRP-2 has displayed the ability to enhance sleep quality by extending the duration of stages 3 and 4 in the sleep cycle by approximately 50% each. It also increases REM (rapid eye movement) sleep by roughly 20% while reducing deviations from “normal sleep” by up to one-third. This improvement in sleep patterns contributes to enhanced cognitive function, stabilized blood pressure, accelerated healing processes, and increased energy levels. While these findings hold benefits for all adults, they are especially significant for the elderly, who often experience reduced sleep quality due to the effects of aging. GHRP-2 offers insights into the potential to optimize sleep for improved quality and efficiency, potentially allowing individuals to reap the benefits of a full night’s sleep in less time.

6. Pain Perception Modulation: Initially, the pain relief observed in animal models of osteoarthritis was attributed to GHRP-2’s ability to elevate growth hormone levels and expedite tissue healing. However, researchers noticed that the pain alleviation occurred before the healing process, suggesting that GHRP-2 might directly influence pain perception. Further investigation revealed that GHRP-2 acts on opioid receptors.

There are four known opioid receptors, each with distinct functions. Traditional opioid pain medications often affect all these receptors, leading to various side effects. GHRP-2, on the other hand, is a selective opioid receptor agonist, primarily binding to receptors responsible for pain relief, sedation, and addiction. This selectivity offers the potential to develop opioid agonists with reduced undesirable effects such as respiratory depression and addiction.

GHRP-2’s side effects are generally minimal to moderate, with low oral bioavailability and excellent subcutaneous bioavailability in mice. It’s important to note that the dosage per kilogram used in mice does not directly translate to humans. GHRP-2 available at Peptide Sciences is strictly intended for educational and scientific research purposes, not for human consumption. It should only be acquired by licensed researchers.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.


The product information featured on this website pertains exclusively to in-vitro studies. In-vitro studies, also known as ‘in glass’ studies, are conducted outside of living organisms. It’s important to emphasize that these products do not constitute medicines or drugs and have not received FDA approval for the prevention, treatment, or cure of any medical conditions, ailments, or diseases. It is crucial to note that the introduction of these products into the bodies of humans or animals is strictly prohibited by law.