Peptides > GHK-Cu 50mg (Copper Peptide)

GHK-Cu 50mg (Copper Peptide)

GHK-Cu is a natural peptide in human blood plasma, urine, and saliva. Research in animals reveals that GHK-Cu can improve wound healing, immune function, and skin health by stimulating collagen, fibroblasts and promoting blood vessel growth. There has been evidence that has shown that it acts as a feedback signal that is generated after tissue injury. It also suppresses free-radical damage and thus is an potent antioxidant.

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.


1. What is GHK-Cu?


2. Molecular Structure of GHK-Cu


3. Research on GHK-Cu

What is GHK-Cu?

GHK-Cu is a naturally occurring peptide first isolated from human blood plasma. It has since been identified in urine and saliva as well. Research into GHK-Cu has found the short peptide to have substantial benefits in wound healing and immune function. It has anti-aging properties and has been found to suppress free-radical damage, increase protein synthesis, fight bacteria, and increase the health of skin and skin fibroblasts.

Molecular Structure of GHK-Cu

Sequence: Gly-His-Lys.Cu.xHAc
Molecular Formula: C14H23CuN6O4
Molecular Weight: 340.384 g/mol
PubChem CID: 73587
CAS Number: 89030-95-5

Source: PubMed
Source: PubMed

Research on GHK-Cu

  1. GHK-Cu’s Role in Skin Regeneration GHK-Cu, a natural component of human blood, plays a crucial role in skin regeneration. Studies on skin cultures have revealed that GHK stimulates the production and breakdown of key skin components, including collagen, glycosaminoglycans, proteoglycans, and chondroitin sulfate. This effect is partially mediated by its ability to attract and coordinate the activity of fibroblasts, immune cells, and endothelial cells at the site of injury. GHK-Cu is commonly found in skincare and cosmetic products, where it enhances skin elasticity, tightens and firms the skin, reduces sun damage, hyperpigmentation, fine lines, and wrinkles. It also helps in scar reduction, prevents hypertrophic healing, smoothes rough skin, and rejuvenates aged skin, partly through its influence on transforming growth factor-Β and gene transcription.

Studies in mice have shown that GHK-Cu accelerates the healing process by up to 33% following burns, not only by recruiting immune cells and fibroblasts but also by promoting blood vessel growth, particularly crucial in burn wound care due to the cauterization effect.

  1. GHK-Cu’s Antimicrobial Properties The presence of foreign pathogens in tissues can significantly impede the wound healing process. Bacterial and fungal infections are particularly problematic in patients with burns or compromised immune systems, such as diabetes or HIV. GHK-Cu, in combination with specific fatty acids, forms a potent antimicrobial compound effective against various bacteria and fungi that often hinder wound healing. Research in diabetic patients has demonstrated that the addition of GHK-Cu to standard care regimens leads to a significant 40% increase in wound closure and a 27% reduction in infection rates compared to control groups. Similar benefits were observed in patients with ischemic open wounds.

  2. GHK-Cu’s Impact on Cognition and Nervous System Function The mechanisms behind neuron degeneration in conditions like Alzheimer’s remain poorly understood, posing challenges in developing effective treatments. However, studies suggest that GHK-Cu can counter the age-related decline in neuron function, a common factor in these diseases. GHK-Cu has been shown to enhance angiogenesis in the nervous system, promote nerve growth, and reduce inflammation in the central nervous system. There is even evidence indicating that GHK-Cu can reset abnormal gene expression and contribute to restoring a healthy state in dysfunctional systems.

GHK-Cu is naturally present in significant concentrations in the brain but declines with age. Scientists hypothesize that this decline in GHK-Cu may contribute to the vulnerability of nervous system tissues to natural insults, such as gene dysregulation, potentially playing a pivotal role in neurodegeneration, beyond the onset of new disease processes.

Source: PubMed

Research involving rodents suggests that GHK-Cu may safeguard brain tissue by inhibiting apoptosis, possibly through modulation of the miR-339-59/VEGFA pathway, a recognized pathway involved in brain injuries. GHK-Cu shows promise in ameliorating neurological deficits, reducing inflammation, and preventing neuron loss associated with excessive miR-339-5p expression[9].

  1. GHK-Cu and Mitigating Chemotherapy Side Effects Studies in mice indicate that GHK-Cu has the potential to shield the lungs from fibrosis induced by the cancer drug bleomycin[10]. This could open the door to utilizing GHK-Cu as an adjunct to chemotherapy, permitting higher drug doses without a corresponding increase in adverse effects. Researchers have also identified a likely mechanism by which GHKC-Cu counters fibrosis, involving the regulation of TNF-alpha and IL-6 levels, both of which are inflammatory molecules affecting lung structure. By reducing lung inflammation, GHK-Cu averts fibrotic changes and enhances collagen deposition.

Similarly, GHK-Cu exhibits lung protection in mouse models of acute respiratory distress syndrome (ARDS), a swiftly progressing and potentially fatal lung condition linked to injuries, infections, and certain chemotherapy drugs. Once more, GHK-Cu appears to act by decreasing TNF-alpha and IL-6 expression[11].

  1. GHK-Cu and Alleviating Pain In rat models, GHK-Cu administration displays a dose-dependent effect on pain-related behavior, potentially through elevating levels of the natural pain-relieving amino acid L-lysine[12]. Further studies also reveal GHK-Cu’s capacity to increase L-arginine levels, another pain-alleviating amino acid[13]. These findings open up new avenues for pain management, reducing reliance on addictive opiates and NSAIDs, which have been associated with cardiac side effects.

GHK-Cu demonstrates minimal side effects, strong oral and subcutaneous bioavailability in mice. However, dosage per kilogram in mice cannot be directly translated to humans. GHK-Cu, available from Peptide Sciences, is intended for educational and scientific research purposes only and is not for human consumption. It should only be purchased by licensed researchers.


Buy Bacteriostatic Water from Our #1 Choice Supplier


The product information featured on this website pertains exclusively to in-vitro studies. In-vitro studies, also known as ‘in glass’ studies, are conducted outside of living organisms. It’s important to emphasize that these products do not constitute medicines or drugs and have not received FDA approval for the prevention, treatment, or cure of any medical conditions, ailments, or diseases. It is crucial to note that the introduction of these products into the bodies of humans or animals is strictly prohibited by law.