Peptides > Epithalon-Epitalon

Epithalon (Epitalon)

Epithalon, also known as Epitalon, is a synthetic compound derived from Epithalamin. It holds promise as a potential regulator of telomerase, the enzyme responsible for safeguarding and extending the protective caps known as telomeres at the tips of DNA strands within chromosomes. Scientific studies indicate that Epithalon has the capacity to stimulate telomere elongation, which could potentially counteract the signs of aging.

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.


1. Introduction to Epithalon


2. Molecular Structure of Epithalon


3. Research on Epithalon

Epithalon Introduction

Epithalon, which is also referred to as Epitalon, Epithalone, or Epithalamin, is a brief synthetic peptide renowned for its ability to activate the telomerase enzyme and trigger the release of melatonin. Initially formulated in Russia during the 1980s, Epithalon has demonstrated the capacity to postpone age-related alterations in the reproductive and immune systems, as well as extend the lifespan of mice and rats. While it primarily garners attention within the field of anti-aging research, Epithalon has displayed notable impacts in specific cancer types, infectious diseases, and the regulation of DNA.

Epithalon Molecular Structure


Sequence: Ala-Glu-Asp-Gly
Molecular Formula: C14H22N4O9
Molecular Weight: 390.349 g/mol
PubChem CID: 219042
CAS Number: 307297-39-8


  • Unlocking the Power of Epithalon for Anti-Aging Benefits

    Early studies involving insects and rodents have illuminated the remarkable potential of epithalon in extending life. In these studies, epithalon demonstrated an impressive 52% reduction in mortality among healthy fruit flies and rats. For mice predisposed to both heart disease and cancer, epithalon showcased the ability to extend lifespan by up to 27% when compared to control groups. A significant aspect of epithalon’s mechanism lies in its capacity to neutralize free radicals, those charged molecules that wreak havoc on healthy tissues.

    However, epithalon’s life-extending prowess isn’t solely attributed to its antioxidant properties. Substantial in vitro research on human somatic cells indicates that epithalon activates an enzyme known as telomerase. Telomerase serves as a guardian for telomeres, the crucial endcaps of chromosomes responsible for maintaining DNA integrity. Epithalon’s activation of telomerase leads to a reduction in DNA strand errors, supporting the concept that it safeguards DNA from damage. In essence, epithalon shields DNA from accumulating errors over time, a process that eventually leads to cellular dysfunction, aging, and, in some cases, cancer.

  • Epithalon: Empowering DNA Activation

    Neither its impact on free radicals nor its influence on telomeres alone can fully elucidate the profound effects of epithalon on longevity. Scientists are actively delving into the mechanisms through which this short peptide operates, aiming to explore them in depth. Interestingly, epithalon appears to alter the expression of specific genes.

    Cellular studies reveal that epithalon directly interacts with DNA, promoting and enhancing the expression of specific genes. Epithalon engages with the promoter regions of genes responsible for CD5, IL-2, MMP2, and Tram1. CD5 and IL-2 exert influence on the immune system, while MMP2 plays a pivotal role in preserving the extracellular matrix within skin, tendons, and other connective tissues. These findings suggest that epithalon may impact immune system functionality and the body’s capacity to heal itself, not only after injury but also in response to everyday stressors.

    It’s not surprising that epithalon influences the immune system, as research in rats indicates that it augments the expression of interferon gamma in aging lymphocytes. Interferon gamma plays a crucial role in the immune system by facilitating the fight against viral infections through the activation of macrophages, natural killer cells, and T cells.

    Here are some confirmed DNA interactions of epithalon:

    • CD5 – Encourages immune cell differentiation
    • IL-2 – Enhances IL-2 production, regulating white blood cells
    • MMP2 – Amplifies MMP activation, reducing inflammation
    • Tram1 – Boosts protein production
    • Arylalkylamine-N-acetyltransferase – Augments melatonin production
    • pCREB t – Regulates circadian rhythm and exhibits anti-neoplastic effects
    • Telomerase – Elevates telomerase activity for prolonged cell lifespan
  • Epithalon and the Radiance of Skin

    As mentioned earlier, epithalon exerts a positive influence on the gene governing MMP2, a protein present in connective tissues such as skin. Studies in rodents indicate that epithalon not only activates this gene but also stimulates fibroblasts, the cells responsible for producing and maintaining MMP2, collagen, and elastin, which constitute the extracellular matrix. Mice exposed to epithalon exhibit a notable 30-45% increase in fibroblast activation. By activating fibroblasts, epithalon contributes to accelerated healing rates and counters the natural decline in skin structure and integrity associated with aging.

  • Epithalon and Inhibition of Tumor Growth

    Daily administration of epithalon to rats afflicted with cancer has shown promising results in curbing tumor growth. Notably, this peptide not only hinders tumor growth but also prevents the metastasis or spread of these tumors to distant tissues. Epithalon is presently under investigation as a potential treatment for Her-2/neu positive breast cancers and holds promise in averting the development of certain types of leukemia and testicular cancer.

    There is some indication that epithalon activates the PER1 protein gene, found in the hypothalamus. PER1, a regulator of circadian rhythms, tends to be underexpressed in cancer patients. Whether this underexpression precedes cancer development or results from it remains unclear. However, it is evident that the protein affects cancer growth once established. Control over PER1 expression might offer a natural means of slowing tumor progression. Research demonstrates that enhanced PER1 expression sensitizes cells to radiation effects, potentially reducing the necessary radiation doses for treating certain cancers. This not only mitigates immediate side effects but also lowers the risk of secondary tumors following high-dose radiation exposure.

  • Epithalon and Melatonin Regulation

    Melatonin, closely linked to sleep and aging, is synthesized and released by the pineal gland. Studies in rats indicate that epithalon and similar peptides influence the synthesis and release of melatonin by modulating the expression of two critical proteins: arylalkylamine-N-acetyltransferase (AANAT) and pCREB transcription protein. Both these genes play pivotal roles in melatonin production and the circadian control of melatonin release. Research involving monkeys suggests that epithalon restores melatonin secretion to normal levels.

  • Epithalon and Visual Health

    In a trial involving rats with retinitis pigmentosa, epithalon demonstrated improved outcomes in 90% of cases. It appears that this peptide helps preserve the normal structure of the eye while enhancing the bioelectric function of the retina, crucial for vision.

    It’s worth noting that epithalon exhibits minimal side effects, boasts low oral and excellent subcutaneous bioavailability in mice. However, dosages per kilogram in mice do not translate directly to human dosages. Epithalon available at Peptide Sciences is strictly intended for educational and scientific research purposes and is not meant for human consumption. Please only purchase epithalon if you are a licensed researcher.

Slowed tumor growth in mice exposed to epithalon compared to controls
PER1 Causes Increased Rates of Ionizing Radiation-Induced Cell Death

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.


The product information featured on this website pertains exclusively to in-vitro studies. In-vitro studies, also known as ‘in glass’ studies, are conducted outside of living organisms. It’s important to emphasize that these products do not constitute medicines or drugs and have not received FDA approval for the prevention, treatment, or cure of any medical conditions, ailments, or diseases. It is crucial to note that the introduction of these products into the bodies of humans or animals is strictly prohibited by law.