Peptides > Chonluten (Bioregulator)

Chonluten (Bioregulator)

Chonluten is a concise peptide bioregulator renowned for its influence on gene expression. Scientific investigations have illuminated its highest activity within lung tissue, with the gastrointestinal (GI) tract displaying secondary levels of activity. Chonluten’s prowess lies in its ability to regulate genes associated with inflammation and antioxidant processes, alongside genes orchestrating proliferation responses to inflammation.

The Impact of Chonluten on Pulmonary Mucosal Function: Chonluten emerges as a pivotal player in regulating pulmonary mucosal function. This holds significant promise for addressing chronic inflammatory conditions afflicting the lungs, such as asthma and chronic obstructive pulmonary disease (COPD). By modulating gene expression, Chonluten has the potential to mitigate inflammation, enhance antioxidant mechanisms, and fine-tune the body’s responses to inflammatory triggers.

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1. Introduction to Chonluten


2. Chonluten Structure


3. Tripeptides in Bioregulation


Chonluten, alternatively known as tripeptide T-34, has emerged as a subject of extensive research. The findings indicate that Chonluten plays a pivotal role in the regulation of gene expression, specifically targeting genes associated with antioxidant and anti-inflammatory pathways. Its effects are particularly pronounced in the lungs and the gastrointestinal (GI) tract.

A Tool for Geroprotection and Lung Health: The compelling research on Chonluten sheds light on its dual role. Firstly, it exhibits geroprotective properties, contributing to the deceleration or prevention of the aging process. Secondly, it serves as an anti-inflammatory agent, with a prominent impact on lung health. Notably, Chonluten appears to normalize mucosal function within the lungs, offering potential therapeutic benefits for conditions like chronic obstructive pulmonary disease (COPD).

These insights underscore the multifaceted potential of Chonluten in enhancing overall well-being, particularly in the context of age-related concerns and lung-related inflammatory disorders. Further research promises to unravel additional facets of Chonluten’s capabilities and applications.

Chonluten Structure


Molecular Formula: C11H17N3O8
Molecular Weight: 319.27 g/mol
PubChem CID: 194641
CAS No: 75007-24-8
Alternative Names: T-34 tripeptide, EDG

Tripeptides in Bioregulation

The Impact of Short Peptides on Longevity: Animal studies have revealed that a range of small di-, tri-, and tetrapeptides can extend life spans by up to 40%. These peptides exert their effects by inhibiting the development of both spontaneous and induced tumors. Scientists speculate that certain tripeptides may play a role in regulating gene expression as well as cellular processes, including apoptosis.

Peptide-Mediated Gene Regulation: Research indicates that short peptides can regulate all aspects of gene expression, including epigenetic DNA methylation. Computational models have illustrated that a single short peptide can effectively govern dozens of genes by penetrating both cytoplasmic (cell) and nuclear membranes to bind directly to DNA via a simple docking method at promoter, suppressor, and other DNA control regions.

Dr. Vladimir Khavinson’s Expertise: With Russia’s significant contributions to the isolation and development of peptides and peptide bioregulators, it is no surprise that Dr. Vladimir Khavinson, the director of the St. Petersburg Institute of Bioregulation and Gerontology, has emerged as a leading authority on Chonluten. Dr. Khavinson’s work underscores the capacity of Chonluten and similar short peptides to directly interact with DNA, influencing its expression. These peptides are paving the way for a new era in both health and disease management as individuals age.

Chonluten’s Influence on Lung Health: Chonluten appears to exhibit specific activity within lung tissue, orchestrating alterations in DNA expression to normalize bronchial mucosal function. The bronchial mucosa serves as a crucial barrier between external inhaled substances and the body’s internal systems. Inflammatory conditions such as asthma or COPD can disrupt this mucosal lining, leading to changes in mucus production and extracellular matrix structure. Chonluten has shown promise in regulating genes associated with this process, including c-Fos, HSP70, SOD, COX-2, TNF-alpha, and antioxidant system genes. This regulation primarily manifests as anti-inflammatory effects, potentially addressing the pathophysiological changes observed in asthma and COPD.

Chonluten’s Role in Addressing COVID-19: Amid the global COVID-19 pandemic, the anti-inflammatory properties of Chonluten have drawn significant interest from scientists. Research indicates that Chonluten and its relative, Bronchogen, exhibit effectiveness in treating bronchopulmonary pathology. Chonluten has shown the potential to enhance standard therapy for chronic bronchitis with an asthmatic component, while also offering stress-protective effects. Given these attributes and Chonluten’s ability to enhance physical performance in low-oxygen environments, it may serve as a valuable component in a comprehensive approach to combatting COVID-19.

Exploring Chonluten’s Impact on the GI Tract: Chonluten’s effects in the gastrointestinal (GI) tract are akin to those observed in the lungs, albeit with less intensity. Preliminary research suggests that Chonluten may hold promise in reducing inflammation and vascular changes associated with inflammatory conditions like Crohn’s disease and ulcerative colitis. Ongoing studies aim to further elucidate Chonluten’s role in GI health.

Chonluten in Summary: Chonluten stands as a short peptide regulator of gene expression, exhibiting heightened activity in lung tissue and secondary activity in the GI tract. Its regulatory effects encompass genes related to inflammation, antioxidant activity, and those involved in proliferation responses to inflammation. The potential applications of Chonluten in addressing chronic inflammatory lung diseases, such as asthma, underscore its significance. It is worth noting that Chonluten demonstrates minimal side effects, boasts low oral bioavailability, and displays excellent subcutaneous bioavailability in mice. However, its mouse dosage per kilogram does not directly scale to humans. Chonluten, available for research purposes at Peptide Sciences, is not intended for human consumption and should only be purchased by licensed researchers.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.


The product information featured on this website pertains exclusively to in-vitro studies. In-vitro studies, also known as ‘in glass’ studies, are conducted outside of living organisms. It’s important to emphasize that these products do not constitute medicines or drugs and have not received FDA approval for the prevention, treatment, or cure of any medical conditions, ailments, or diseases. It is crucial to note that the introduction of these products into the bodies of humans or animals is strictly prohibited by law.